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In our previous posts, we discussed the significance of macromolecular interactions in driving biological discoveries and biotechnological advancements. We highlighted how label-free techniques, such as Bio-Layer Interferometry (BLI), can effectively evaluate binding affinities in these interactions. Early attention was directed towards understanding protein-protein interactions, which have played pivotal roles in shaping new biologics with therapeutic…

While grassroot methods such as two-hybrid screening and affinity tags continue to be used as the initial step in many present-day studies of biomolecular interactions, an increasing number of modern laboratories are adopting label-free platforms like Bio-Layer Interferometry (BLI). These techniques not only offer greater sensitivity and speed but also provide real-time data on interactions.At…

Biomolecules such as proteins, nucleic acids, and polysaccharides serve as the building blocks of all organisms, but it’s the interaction among these molecules that plays an even more critical role in biology. Therefore, understanding these interactions is central to biological sciences and essential for biomedical research, environmental monitoring, therapeutic developments, and more. Two different approaches…